SYNTHESIS OF N-BENZAMIDOMETHYL - 4 –TOLUENESULFONAMIDE BY TWO DIFFERENT SYNTHETIC METHODS

Agron ALILI, Zulxhevat ABDIJA, Shemsedin ABDULI

Abstract

Sulfonamide drugs paved the way for the antibiotic revolution in medicine. The sulfonamide chemical part is also present in other medications that are not antimicrobials, including thiazide diuretics, loop diuretics, anti-diabetic drugs, COX-2 inhibitors, etc. To make new derivatives of sulfa-drugs, test reactions by different synthetic procedures were performed to obtain N-benzamidomethyl-4-toluenesulfonamide. By two different synthetic procedures, N-benzamidomethyl-4-toluenesulfonamide was obtained in high yields. Reaction) with 4-toluene sulfonamides and (benzamidomethyl)triethylammonium chloride were performed at room temperature in ethanol/water solutions (pH ≥ 9). The other synthetic method was performed in dichloromethane or water depending on the solubility of N-benzamidomethylamine. The structure of N-Benzamidomethyl -4-toluenesulfonamide was confirmed and characterized by IR, 1H–NMR, 13C–NMR, UV, and MS spectrometry.

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