STUDY ON THE IMPACT OF METFORMIN ON THE EFFECT OF PALM OIL IN THE METABOLISM OF CARBOHYDRATES

Besim Memedi, Nadka Bojaxhieva, Arian Idrizaj

Abstract

Introduction: Research has been published on the frequency of Metformin use in patients with various complications who have been using fat-rich foods. Our analysis of a large number of studies shows that: in parallel with the improvement of the function of the liver, insulin resistance is also improved. In the recent years, studies have been conducted on the impact of Metformin mechanisms on the insulin resistance. Purpose of the Presentation: the attempt to study the impact of Metformin on the laboratory mice, treated for a longer period of time, continuously with palm oil. Materials and Methods: experiments were conducted on adult male mice, divided into 4 groups, each group with 5-6 experimental animals. Palm oil and Metforminwas applied per os. The period between palm oil and metformin appliance was 4-5 hours of difference. The experiments were carried out at the Medical University of Sofia, at the Scientific Research Laboratory of the Department of Pharmacology and Toxicology Results: Figure 1 shows significant statistical differences between the research group with palm oil and the research groupwith palm oil + Metformin, on the 60th day of the study. The continuation of Metformin's admission along with the palm oil reduces body weight gain of the experimental animals. Figure 2 shows the results of TTG (Glucose Tolerance Test).The analysis of these data shows that, under the influence of palm oil, prediabetes is developed. However, under the influence of Metformin, this condition of prediabetes is prevented. This can be seen from the results of the use of palm oil + the group treated with Metformin. Figure 3 shows the results of the determination of INF-? on the 30th and 60th dayof the experiments on the adult animals. The results show that palm oil reduces the level of interferon gamma. Metformin antagonizes the suppressive effect of palm oil in the interferon gamma.

Pages: 152 - 158