LIPID VARIABLES IN RELATION TO CORONARY ARTERIES ATHEROSCLEROSIS EXTENT IN ST ELEVATED ACUTE MYOCARDIAL INFARCTION

Atilla Rexhepi, Valon Asani, Fisnik Demiri, Vlora Ibrahimi

Abstract

Aim: The association between different lipid profiles and the extent of the coronary lesion in acute myocardial infarction (AMI) has been rarely reported in epidemiological and clinical studies. This study aimed to evaluate the association between different lipid profiles and the extent of coronary atherosclerotic disease lesions in patients with acute myocardial infarction (AMI). Method: In our study, we analyzed data for 50 consecutive patients, with acute myocardial infarction undergoing coronary angiography at the Clinical Hospital of Tetovo. Patients were classified by coronary angiography into one-vessel disease (1VD), two-vessel disease (2VD), and three-vessel disease (3VD), with obstructive coronary artery disease (CAD), defined as =50% angiographic stenosis. Laboratory analysis for lipid fractions was performed. Results: One-way analysis of variance, showed a statistically significant association between the mean of total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL) and the number of coronary arteries involved with an obstructive lesion (p=0.021). No significant association showed between extent of coronary artery lesion and non-HDL (p=0.33), HDL (p=0.438), low density lipoprotein cholesterol (LDL) (p= 0.713), triglycerides (TG) (p=0.352), and TG/HDL ratio (p=0.143). In multiple regression analysis, TC/HDL ratio value statistically significantly predicted the extent of the coronary atherosclerotic lesion (p=0.044). Conclusion: The results of our study showed that TC to HDL ratio (TC/HDL), appeared as the most powerful marker of extension of the coronary lesion in patients with AMI. In patients with suspected CAD, this fact makes it possible for the TC / HDL ratio to be used as an easy and non-invasive method to measure the extent and severity of coronary heart disease.

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