THE IMPORTANCE OF PRENATAL SCREENING OF SERUM BIOMARKERS OF QUADRIPLE TEST AND FETOPLACENTAL UNIT IN THE PREDICTION OF PERINATAL RISK AND PREGNANCY OUTCOME

Pranvera Izairi, Nevenka Velickova, Marjan Stojovski, Asim Izairi

Abstract

Fetal compromise of uteroplacental blood flow leads to utero-placental insufficiency. This study aimed to find a correlation between serum biomarkers from Quadriple test and fetoplacental unit, in the second trimester of pregnancy, as possible predictors for the adverse perinatal outcome. Material and method: This cohort study was conducted in a SHOG “Mother Theresa”, Skopje, from November 2019 to June 2021. It includes 673 second trimester pregnant women, followed up and monitored till delivery. Results: From 673 respondents, 523 that is 77.7% made up the control group, while 150 that is 22.3% of pregnant women made up the examined group. From the examined group, 48 (7.13%) had preeclampsia, 32 (4.75%) had pregnancy-induced hypertension, 20 (2.97%) had a small fetus for gestational age, and 50 (7.43%) had intrauterine growth retardation. Discussion: high values of Inhibin A in pregnant women with adverse outcome, statistically was confirmed as significant, while HCG values were significantly higher in group with preeclampsia. Pregnant women with preeclampsia significantly more often than pregnant women from control group had higher values of serum AFP, and it wasn’t found significantly statistical difference in medial values of unconjugated Estriol in four examined groups compared to control group. It was confirmed the hypothesis that the placental volume by screening in second trimester is important for pregnancy outcome, as well as the flows in uterine and umbilical arteries. Conclusion: Inhibin A value as a single marker for adverse pregnancy outcome was the best predictor, while the combination of biomarkers from Quadriple test and the uterine arteries flow in the second trimester of pregnancy, represents the best differentiating ability test for pregnant women for adverse and favorable pregnancy outcome.

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