CONCENTRATIONS OF PLGF MOLECULE IN THE EVALUATION OF HYPERTENSIVE CONDITIONS ON PREGNANCY AND ESPECIALLY PREECLAMPSIA – A REVIEW

Valbona Gjonbalaj Rustemi, Nadi Rustemi, Florin Besimi

Abstract

How pregnancy incites or aggravates hypertension remains unsolved despite decades of intensive research. Indeed, hypertensive disorders remain among the most significant and intriguing unsolved problems in obstetrics. Preeclampsia is a systemic syndrome that seems to originate from the placenta and is associated with an imbalance between angiogenic factors in the maternal circulation. PLGF (placental growth factor) is an increasingly important molecule in the prediction, diagnosis, and treatment of pre-eclampsia. It has pro-angiogenic effects on the fetoplacental circulation and supports trophoblast growth. The effect of antihypertensive therapy and also evaluation of laboratory findings, ultrasonographic examinations, blood pressure values, and concomitant diseases of patients with hypertensive disorders in pregnancy are very important. Placental growth factor (PLGF) is an increasingly important player in the clinical management of pre-eclampsia.

Pages: 175 - 183