EFFICACY AND RATIONALE BEHIND COMBINATION OF THE ANTIOXIDANT THERAPY IN MEN WITH OLIGOASTENOZOOSPERMIA AND ELEVATED CASPASE-3 ACTIVITY

Vegim Zhaku, Sheqibe Beadini, Xheladin Çeka, Nexhbedin Beadini, Naser Durmishi

Abstract

The rate of male infertility globally without exception has attracted the attention of healthcare professionals and pharmaceutical companies. To verify the effectiveness of combination therapy with antioxidants as recommended in some elaborated papers in major medical libraries such as PubMed, Cochrane, Scopus, and Elsevier, a total of 57 individuals were enrolled in the study after fulfilling the inclusion criteria. Standard semen analysis along with biochemical analysis of Caspase-3 levels was done before receiving therapy and after six months. The groups were randomly divided into the individuals who received the combination of the antioxidant formula (n=34) and the individuals who received placebo therapy (n=23). After 6 months of treatment, there was an improvement in concentration (mean & SD, 31.26 ± 3.39) and motility (46.18 ± 5.97) in the group that had received antioxidant therapy for 6 months with statistically significant difference (p<0.001), whereas the placebo group showed no statistically significant improvement after the 6 months in concentration (9.96 ± 3.23; p=0.950) nor in motility (30.52 ± -5.29; p=103). In the group treated with antioxidants, we had a reduction in caspase-3 activity (2.21 ± 0.62; p <0.001), whereas in the placebo group the mean caspase-3 activity had no statistically significant changes (4.05 ± 0.73; p=0.275). Such therapy seeing the cost-benefit of the same in situations when the consequence of male infertility is increased free radical activity is justified and contributes positively to the process of conceiving natural fertilization.

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