DENTAL IMPLANT PLACEMENT IN PATIENTS ON BISPHOSPHONATE THERAPY

Jeton NEZIRI, Sahmedin SALI

Abstract

Bisphosphonates are antiresportive medications used to prevent and treat a wide range of diseases such as osteoporosis, Paget disease of bone, malignancies metastatic to bone, multiple myeloma and hypercalcemia of malignancy. One of the most important complications at the patients who are taking therapy with bisphosphonates is osteonecrosis of the jaw related to bisphosphonates (BRONJ). This review aimed to consider dental implant placement in patients who have been treated with or are currently on bisphosphonate medication, based on research using electronic databases PubMed, Google Scholar and Elsevier, under the following keywords: dental implants, bisphosphonates, ostheonecrosis, BRONJ . We performed a literature review to explore the relation between dental implants and bisphosphonates depending on several factors such as the way of administering (oral or venous), the length of the therapy, the dose of the medicine, other chronic therapies that the patient has taken and which affects the bisphosphonates. The way of administering bisphosphonates is crucial because patient treated with intravenous bisphosphonates seemed to have a higher chance of developing implant-related osteonecrosis of the jaw. The intraorally treated patient group appeared to have more successful results. Benefits that bisphosphonates offer to patients clearly outbalance the risk of potential side effects; however, any patient for whom prolonged bisphosphonate therapy is indicated, should be provided with preventive dental care in order to minimize the risk of developing this severe condition and to have high success rate of dental implants.

Pages: 219 - 223