COLON ADENOCARCINOMA WITH SQUAMOUS DIFFERENTIATION: CASE REPORT

Learta V, Adelina E

Abstract

Objective: Adenosquamous carcinoma of the colon is a colon neoplasm composed of separate malignant squamous and glandular components. This rare subtype has an incidence of < 0.1% and features of both adenocarcinoma and squamous cell carcinoma, similar to adenosquamous carcinomas seen elsewhere in the gastrointestinal tract. Case report: We report a case of a 43 year old female patient who was diagnosed with colon cancer after colonoscopic examination with biopsy. The patient underwent left colon resection (sigmoid colon) and the specimen was sent to histopathologic department. After gross dissection was revealed an obstructive polypoid and ulcerative mass with 5.6x5.2 cm, with an invasion in fat tissue and with serosal perfoaration. Histopathological views from tissue specimens showed an admixture of distinct components of both adenocarcinoma and squamous cell carcinoma approximative 10 % of total tumor mass). Discussion: Herxheimer reported the first instance of colorectal adenosquamous carcinoma in 1907, describing it as a tumor with elements of both adenocarcinoma and squamous cell carcinoma. Other potential causes of epidermoid carcinoma that develop in the large intestine must be ruled out in order to make the diagnosis of primary colorectal adenosquamous carcinoma.

Pages: 228 - 233