A REVIEW OF COUMARIN DERIVATIVES IN PHARMACOTHERAPY

Lulzime BALLAZHI, Edita ALILI-IDRIZI, Merita DAUTI, Hanife RUSTEMI-AHMETI, Drita YZEIRI-HAVZIU

Abstract

Coumarins are proven precursors in the synthesis of many medicinal compounds and the heterocycles derived from them are widely appreciated for their numerous pharmacological effects. Molecules containing coumarin rings have been studied for their antiviral, antimicrobial, antifungal, anti-inflammatory, anticonvulsant, anticoagulant, antipsychotic, and anticancer effects. Thus, the isolation, structural characterization, and pharmacological evaluation of new derivatives combining coumarin rings continuously provoke research interest. In this paper, a brief overview of the chemical, biopharmaceutical, pharmacokinetic, and pharmacological properties, as well as the structure-activity relationship for many coumarin derivatives, is given, with a special focus on new compounds as potential chemotherapeutics or key components for the synthesis of drugs intended for the treatment of cancer.

Pages: 234 - 243