POTENTIAL IMPACT OF CYTOMEGALOVIRUSES CMV, IGG, IGM, TOXOPLASMOSIS TXM AND TXG AS POTENTIAL CAUSES OF STERILITY AND ABORTION IN PREGNANT WOMEN

Rufati N, Beadini N, Rexhepi M, Besimi F

Abstract

Abortion can be attributed to a certain number of factors affecting the human reproductive system. Maternal and genetic abnormality, immunological dysfunction and endocrine, infectious agents, external pollutants, psychogenic factors and endometriosis are the most common factors. Generally, various infections affecting the mother can lead to bacteremia and infection with viruses that causes abortion. The most frequent infectious agents with a high risk of causing abortion include the TORCH complex (Toxoplasma gondii, Rubella virus, Cytomegalovirus, Herpes simplex virus) and other agents such as Coxsackie virus, Ureaplasma urealyticum, Mycoplasma hominis, Chlamydia trachomatis, Treponema pallidum , Niesseria gonorrhoeae, HIV and others. All of these agents have a widespread environmental disruption and their effect on the immune response during pregnancy leading to apoptosis that is observed during the fetal abortion process. This research aims to curb the effect of infections during pregnancy, the infections that lead to spontaneous abortion. This research also contains data on the number of abortions in Tetovo and the vicinity, mainly data for 2012 to June 2017. This research includes data on patients in different months of pregnancy and with a positive history of infections mainly with Toxoplasma or Citomegallovituse. The samples taken from these patients were analyzed for the presence of serum immunoglobulin using ELISA for immunoglobulin and also microbiological tests - antibiogram tests for the presence of infectious ages. Cytomegalovirus and toxoplasma infections may lead to congenital abnormalities in children, especially since it has been infected in the first trimester of pregnancy. While it comes to infection during pregnancy, 40% of the cases pass through the placenta and infect the fetus that may result in the development of cytomegalovirus syndrome and congenital toxoplasmosis.

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