ACTUAL KNOWLEDGE AND FUTURE PERSPECTIVES ON OBSTRUCTIVE AZOOSPERMIA (META-ANALYSIS AND TEXTBOOK REVIEW)

V. Zhaku, Sh. Beadini, N. Durmishi, S. Zhaku

Abstract

In this paper are reviewed and analyzed parts of works of the most prominent scientists and clinicians in the field of male infertility recombined with studies conducted in the Republic of Macedonia. The material was collected from the databases of standard digital libraries. Referring to the data that 10 million males out of 3 billion in a reproductive age are azoospermic, and a number that should not be neglected lives within the Balkan Peninsula, where documented ciphers are lacking on the prevalence of azoospermia. Epigenetic changes are now known to affect gene expression and some genes participating in spermatogenesis have been demonstrated to be epigenetically regulated. Laboratory management of gametes taken surgically requires special attention because sperm retrieval from azoospermatic males is often of compromised quality. In the focus of study were the compared results of successful pregnancy rate, after intracytoplasmic sperm injection (ICSI) and the health of offspring originating from such fathers, with meta-analysis of predictive factors such as etiology, sperm injection technique, and clinical results from assisted reproductive technique (ART). The development of artificial gametes presents challenge and biotechnological perspective. Stem cell research is the field of hope for treating the most severe cases of azoospermia and potential healing of male sterility.

Pages: 46 - 53